is a peptide composed of 29 amino acids secreted by alpha cells in the pancreas. Glucagon is produced by the original glucagon gene, which was originally the precursor glucagon. Glucagon is formed by tissue-specific treatment of glucagon in pancreatic alpha cells, and GLP-1 and GLP-2 are formed in intestinal cells. Glucagon is an anti regulatory hormone that stimulates the production of glucose in the liver to prevent hypoglycemia.
|
|
||
|
16941-32-5 |
||
| C153H225N43O49S | ||
| 685-611-6 | ||
| 3482.75 | ||
| Keep in dark place,Sealed in dry,2-8℃ | ||
| 1.53±0.1 g/cm3(Predicted) | ||
 |
1, Main Medical Applications Function: Glucagon powder can quickly promote the release of stored glucose from the liver. For example, in case of severe hypoglycemia in patients with type 1 diabetes and inability to take sugar orally, emergency use can quickly increase blood sugar. Assessing endocrine function: In the glucagon stimulation test, it is used to evaluate pancreatic beta cell function (such as C-peptide release test) and help diagnose certain pancreatic diseases. Used for imaging examinations: In gastrointestinal radiology examinations, glucagon is sometimes used to temporarily inhibit gastrointestinal peristalsis in order to obtain clearer images. 2, Research and pharmaceutical industry applications As an active pharmaceutical ingredient, it is used to produce the final glucagon medication (such as emergency pens). |
It is used to develop new drugs, such as more stable glucagon analogues, double target agonists (such as GIP/GLP-1/glucagon receptor multi agonists), etc., which is currently the frontier field of diabetes and obesity drug research and development.
Used for studying glucose metabolism, liver function, pancreatic cell physiology and pathology, etc.
As a tool drug, explore its signaling pathway and physiological effects in the laboratory.If you need it, pls click e-mail: sales1@faithfulbio.com.
|
|
|
|
|
White or off-white powder |
||
|
Practically insoluble in Water and in most organic solvents, it is soluble in dilute mineral acids and in dilute solutions of alkali hydroxides. |
||
|
3482.8±1.0 |
3482.8 |
|
|
for each impurity: NMT1.0% |
0.18%(single largest impurity) |
|
|
NLT 98.0% |
99.6% |
|
|
NMT 7.0% |
2.0% |
|
|
NMT 7.0% |
4.1% |
|
|
NLT85% |
93.4% |
|
| Conform with enterprise specification . | ||
is a single chain peptide hormone synthesized and secreted by pancreatic 2 cells. It has the following effects:
|
|
1. Elevated blood sugar effect: It can activate liver phosphorylase, promote liver glycogen breakdown and gluconeogenesis, and increase blood sugar. 2. Positive inotropic effect: can increase intracellular cAMP content, enhance myocardial contractility, increase cardiac output and stroke work. Its positive inotropic effect can still be exerted after sufficient application of cardiac glycosides and is not blocked by propofol. Although it can increase heart rate and raise blood pressure, it does not cause arrhythmia. The mechanism of its production is as follows: ① Activation of adenylate cyclase converts adenosine triphosphate into cyclic adenosine monophosphate, enhancing myocardial contractility; ② Promote liver glycogen breakdown and increase blood sugar levels; ③ Promote the release of blood glucose regulators, improve the utilization of glucose by the myocardium, and promote anaerobic fermentation of the myocardium, thereby improving the energy metabolism of the myocardium. Combined with Digitalis cardiac glycosides, it can increase therapeutic efficacy. |
3. Effect on the kidneys: dilate renal blood vessels, improve renal blood flow, and promote the excretion of sodium, potassium, and calcium.
4. Effect on the digestive system: It can cause smooth muscle relaxation in the stomach and duodenum, small intestine and colon, inhibit peristalsis in the stomach, small intestine and colon, and increase the secretion of bile and intestinal fluid.
5. Effect on the secretion system: Excites the adrenal medulla and promotes the release of Levodopa like substances. It can also promote the secretion of Calcitonin and other substances.
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
|
3-7 days |
|
Suitable for under 50kg. |
|
|
7-15 days |
Suitable for more than 50kg. |
||
|
15-60 days |
Suitable for more than 500kg. |
A:Glucagon helps blood glucose levels rise in multiple ways: Glucagon triggers your liver to convert stored glucose (glycogen) into a usable form. Your liver then releases it into your bloodstream. Glucagon can prevent your liver from taking in and storing glucose so that more glucose stays in your blood.
A:Affected by blood glucose and amino acid levels, hormone levels, and neural regulation.
A:Almost insoluble in water.
: The articles on this website are mainly used for scientific research and academic exchange. Please carefully discern the authenticity of their viewpoints and content. If you discover any infringement. Please contact the administrator promptly. We are not responsible for the consequences of the information and services provided on this website.
: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Popularni tagovi: peptide hormone glucagon powder cas 16941-32-5, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China